I’m not convinced! I’ve had bad luck with aphrodisiacs! — Some guy, “Grampa vs. Sexual Inadequacy”
Though his image may just be a combination of other Simpsons characters (I see a cross between Lenny and Milhouse), the voice of the aphrodisiac-scorned Spittle County rube appears to be a take on a ubiquitous vocal styling popularized by vaudeville-radio-talkie star Ed Wynn.
Wynn’s ululating delivery made him a popular comic actor in a 60-year-long career that took him all over the map, but he’s probably best known in popular culture for his performance as the Mad Hatter in Disney’s animated Alice In Wonderland: